Skin tissue equivalent

This biomedical cell product is a multicomponent tissue-engineered structure, created by analogy with the structure of human skin.

Skin Tissue Equivalent (STE) is intended to restore the skin in patients with extensive and deep burns, as well as in patients with trophic ulcers, bedsores, and other types of chronic wounds.

The dermal component is based on a three-dimensional biodegradable collagen matrix, which is necessary for cell migration and contains layer-by-layer fibroblasts and keratinocytes. The final treatment form of STE is formed directly on the wound.

Local transplantation of STEs makes it possible to create a high initial concentration of functionally active cells on the wound surface. STE provides the synthesis of cytokines and extracellular matrix components, stimulates wound vascularization, proliferation, and differentiation of the patient’s own skin cells. Fibroblasts and keratinocytes in the STE participate in the formation of a full-fledged skin.