{"id":8362,"date":"2024-03-18T16:36:56","date_gmt":"2024-03-18T13:36:56","guid":{"rendered":"https:\/\/ibce.by\/en\/?page_id=8362"},"modified":"2024-05-18T14:51:07","modified_gmt":"2024-05-18T11:51:07","slug":"sector-of-molecular-modeling-and-bioinformatics","status":"publish","type":"page","link":"https:\/\/ibce.by\/en\/sector-of-molecular-modeling-and-bioinformatics\/","title":{"rendered":"Sector of molecular modeling and bioinformatics"},"content":{"rendered":"

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Sector of molecular modeling and bioinformatics<\/h1>\n<\/div>\n<\/div><\/div><\/div><\/div><\/section>
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\nThe sector of molecular modeling and bioinformatics is a structural subdivision of the State Scientific Institution \u201cInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus\u201d and was created in accordance with order No. 26 dated January 30, 2024.<\/p>\n

There are currently 3 employees<\/strong><\/em> working in the sector, including:<\/p>\n

\u2014 head of the sector;
\u2014 senior researcher \u2013 1;
\u2014 junior researcher \u2013 1 (PhD student).<\/p>\n

2 people<\/strong> <\/em>have an academic degree: 1 doctor and 1 candidate of science.<\/p>\n

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Head Of Sector<\/div>
Valerii G. Veresov <\/div>
Doctor of Biological Sciences, Associate Professor\r\nIn 1980, he defended his candidate\u2019s thesis \u201cTransport of ions in \u201cthick\u201d biological membranes\u201d for the degree of candidate of physical and mathematical sciences in the specialty 03.00.02 \u201cBiophysics\u201d, and in 2004 - his doctoral thesis \u201cStructure and mechanisms of functioning of potential-dependent ion channels of biological membranes. Research by means of molecular mechanics\" in the same specialty. Published more than 180 scientific works, including 2 monographs (one published in the USA), 1 chapter in a monograph published in the USA, 17 articles in foreign scientific journals, 87 articles in publications from the Higher Attestation Commission list. For the first time in the world, he modeled the VDAC2, MTCH2, TOM receptors on the outer mitochondrial membrane and established their central role in apoptosis, and also developed a theory of pro-apoptotic displacement of apoptosis effector proteins from mitochondrial receptors by BH3-only proteins, leading to permeabilization of the outer mitochondrial membrane and apoptosis. V.G. Veresov, together with his students, developed a line of antitumor drugs - inhibitors of anti-apoptotic proteins of the Bcl-2 family, as well as a line of antitumor drugs - inhibitors of the PD-1\/PD-L1 interaction, which have high antitumor potential.<\/div><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/section>
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e-mail: veresov@ibp.org.by<\/strong><\/p>\n

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\nThe main objectives of the Molecular Modeling and Bioinformatics Sector are:<\/strong><\/p>\n

\u2014 Conducting fundamental and applied research in the field of immunology, virology, biophysics, bioinformatics, molecular modeling and related disciplines.
\u2014 Molecular modeling. Study of the mechanism of action of various chemical structures (small molecules and synthetic oligomers) that have demonstrated antiviral activity, computer design of their modifications in order to enhance the latter. Search for new structures with antiviral activity, both among small molecules and among natural and synthetic oligomers. Modeling of metabolic pathways associated with the formation of various viruses in cells.
\u2014 Molecular modeling of the interactions of immune molecules, structural modeling of the immunological synapse and the mechanisms of immune checkpoint functioning
\u2014 Bioinformatics and computer-aided design of drugs with antitumor and antiviral activity.<\/p>\n

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