{"id":7059,"date":"2020-06-15T10:27:42","date_gmt":"2020-06-15T07:27:42","guid":{"rendered":"https:\/\/ibp.org.by\/en\/?page_id=7059"},"modified":"2024-01-09T13:48:29","modified_gmt":"2024-01-09T10:48:29","slug":"kultura-mezenhimalnyh-stvolovyh-kletok-zhirovoj-tkani-cheloveka","status":"publish","type":"page","link":"https:\/\/ibce.by\/en\/biomediczinskie-kletochnye-produkty\/kultura-mezenhimalnyh-stvolovyh-kletok-zhirovoj-tkani-cheloveka\/","title":{"rendered":"Mesenchymal stem cells"},"content":{"rendered":"<p><section class=\"kc-elm kc-css-942533 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-714114 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-552376 kc-title-wrap \">\n\n\t<h1 class=\"kc_title\">Mesenchymal stem cells<\/h1>\n<\/div>\n<div class=\"kc-elm kc-css-705638 kc_text_block\"><\/p>\n<p><span style=\"font-weight: 400;\">The biomedical cell product is represented by mesenchymal stem cells (after this &#8211; MSC) of an adult with typical morphology and phenotype. The main properties of MSCs that are valuable for their clinical use are high paracrine and immunomodulatory activity, the ability to self-renewal, and multilinear differentiation potential.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The biomaterial for the production of BMCP is adipose tissue containing 2\u20135% of native MSCs, which is 10\u20131000 times higher than in the corresponding fraction of adherent bone marrow cells. The active proliferation of MSCs in vitro makes it possible to obtain a cell dose sufficient for successful clinical use.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MSCs of adipose tissue has an immunomodulatory effect, suppressing the activity of almost all cells of the immune system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MSCs are capable of induced in vitro differentiation in adipogenic, osteogenic, chondrogenic, endothelial, myogenic, and neurogenic directions, which determines the areas of clinical use of BMCPs based on them. The ability of MSCs to interact with other cells, both in vitro and in vivo, through the production of paracrine factors, exerting immunomodulatory, anti-inflammatory, trophic effects and stimulating angiogenesis is of great importance for clinical efficacy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Methods of cell therapy with the use of MSCs in the treatment of many chronic diseases have been developed, which is manifested by tissue regeneration, elimination of the inflammatory reaction, and restoration of microcirculation.<\/span><\/p>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-500607 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-101223 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-714881 kc-pro-button kc-button-main\">\n\t<a href=\"https:\/\/ibce.by\/en\/wp-content\/uploads\/sites\/18\/2021\/04\/13_reg_msk.pdf\">\n\t\t<span class=\"creative_icon creative_icon_left\"> <i class=\"et-document\"><\/i>  <\/span><span class=\"creative_title\">Registration certificate<\/span>\t<\/a>\n<\/div>\n<\/div><\/div><\/div><\/div><\/section><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":7055,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7059","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/pages\/7059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/comments?post=7059"}],"version-history":[{"count":5,"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/pages\/7059\/revisions"}],"predecessor-version":[{"id":8347,"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/pages\/7059\/revisions\/8347"}],"up":[{"embeddable":true,"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/pages\/7055"}],"wp:attachment":[{"href":"https:\/\/ibce.by\/en\/wp-json\/wp\/v2\/media?parent=7059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}